Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Health Data Research UK Midlands Site, Birmingham, UK. University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK; Health Data Research UK Midlands Site, Birmingham, UK. Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK. Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK; Health Data Research UK Midlands Site, Birmingham, UK. Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. Computer Sciences, University of Birmingham, Birmingham, UK. Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK; Health Data Research UK Midlands Site, Birmingham, UK. Norwich Medical School, University of East Anglia, Norwich, UK. Warwick Medical School, University of Warwick, Warwick, UK. University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Health Data Research UK Midlands Site, Birmingham, UK. Electronic address: g.gkoutos@bham.ac.uk. University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK; Health Data Research UK Midlands Site, Birmingham, UK. Electronic address: d.kotecha@bham.ac.uk.